Fig. 8.
Effects of Pertussis and Cholera toxin pretreatment on ICa modulation in R-B neurons. A: superimposed ICa traces evoked with the double-pulses voltage protocol from control (left), Bordetella pertussis holotoxin (PTX, 500 ng/ml, middle), and Vibrio cholerae holotoxin (CTX, 500 ng/ml, right) preincubating R-B neurons. B and C: bar graphs summarizing the effects of control, PTX and CTX pretreatment on the mean ICa inhibition and facilitation ratio (FR) produced by baclofen or serotonin (5-HT) in R-B neurons, respectively. - - - in bar graph of C indicates the mean FR determined in absence of agonists. Data are presented as means ± SE. The number of neurons tested is indicated in parentheses on the graph. * P < 0.05, *** P < 0.001 1-way ANOVA followed by Dunnett's post hoc tests with control.