Skip to main content
. 2011 Feb;25(2):590–599. doi: 10.1096/fj.10-167304

Figure 5.

Figure 5.

Prognostic value of GIV-fl expression is independent of tumor MSS status. A) Kaplan-Meier survival curves for patients with colorectal cancer, stratified according to microsatellite status alone. Patients with Duke's B2 colorectal cancer were classified according to microsatellite status of their cancer (24). Log-rank analysis of the Kaplan-Meier curves shows that despite a trend that patients with tumors that feature MSI had favorable survival vs. those with MSS, microsatellite status alone is an insufficient predictor of survival (P=0.069). B) Kaplan-Meier survival curves for patients with colorectal cancer, stratified according to microsatellite status in combination with GIV-fl expression status. Patients with Duke's B2 colorectal cancer were classified according to microsatellite and GIV-fl expression status of their tumor. Log-rank analysis of the survival curve shows that when GIV-fl expression (as in Fig. 4B) was applied in tandem with microsatellite status, patients with MSS tumors (n=43) whose tumor epithelium stained negative for GIV-fl (GIV-fl neg) had better survival than patients whose tumor epithelium stained positive (GIV-fl pos) (P<0.0001).