Skip to main content
. 2011 Feb;25(2):644–652. doi: 10.1096/fj.10-169227

Figure 4.

Figure 4.

Increased transport activity of P-glycoprotein, Mrp2, and BCRP in brain capillaries following in vivo dosing of rats with 1 μg/kg or 5 μg/kg TCDD (single i.p. injection, tissues collected 2 d later). A) Representative confocal images showed luminal accumulation of fluorescent substrates NBD-CSA (for P-glycoprotein), TX red (for Mrp2), and BODIPY-prazosin (for Bcrp) in capillaries from control and TCDD-dosed rats. Scale bar = 5 μm. B–D) Dose-dependent increases of transport activity in isolated rat brain capillaries for NBD-CSA (B), Texas Red (C), and BODIPY-prazosin (D). Values are means ± se for 8–12 capillaries from a single preparation (pooled brains from 10 rats). ***P < 0.001 vs. control.