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. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: Hypertension. 2010 Oct 4;56(5):964–972. doi: 10.1161/HYPERTENSIONAHA.110.152298

Figure 2.

Figure 2

Stimulatory effects of 2-ME on prostaglandin synthesis in HASMCs. Panel-A depicts the microarray analysis of transcriptional changes in HASMCs treated with 2-ME (3μmol/L) for 30 hours. Expression levels are depicted as color scale from red (up-regulation) to blue (down-regulation). Gene Set Enrichment Analysis (GSEA) revealed induction of key proteins known to facilitate prostaglandin synthesis. Panel-B shows the significant stimulatory effects of 2-ME on COX-2 protein expression in HASMCs treated with 2-ME. Data are presented as mean±SEM (n=3). *p<0.05 versus vehicle-treated control. Arrows indicate the genes for which protein expression was confirmed.