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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Pharmacol Biochem Behav. 2010 Nov 27;97(4):676–682. doi: 10.1016/j.pbb.2010.11.016

Figure 3.

Figure 3

SA 4503 augments the effect of methamphetamine to substitute for the cocaine SD in a dose-dependent manner. Rats were administered SA 4503, returned to the home cage for 10 min, injected with cocaine, methamphetamine, or d-amphetamine and placed in the chamber 10 min later. Closed symbols represent substitution tests where rats were administered cocaine, methamphetamine, or d-amphetamine in the absence of SA 4503. Open symbols represent pretreatment with 0.81 μmol/kg (open triangles) or 2.7 μmol/kg (open squares) SA 4503. Data represent mean (±SEM) percent of responses on the cocaine-paired lever (Panels A-C) and the mean (±SEM) response rates (Panels D-F). (n = 10 rats/group, except where indicated for a specific drug dose and time point).