FIGURE 7.

KRIBB11 inhibits the induction of HSPs by HSP90 or a proteasome inhibitor. HCT-116 cells were pretreated with the indicated concentrations of KRIBB11 or vehicle solvent (0.1% DMSO) for 30 min and then exposed to 1 μmol/liter 17-AAG or 10 μmol/liter MG132 for 5 h at 37 °C, and whole cell lysates were analyzed by Western blotting as described under “Experimental Procedures.”