FIGURE 1.

Inhibition of wild type β2-m fibrillogenesis by seven tetracycline congeners was followed by thioflavin fluorescence assay. Experiments were carried out in triplicate at different molar drug concentrations (50, 100, 200, 300 μm). Data were normalized and fitted using a standard Hill slope dose-response curve. Means ± S.D. of three experiments are shown for each compound. The structure of doxycycline, the most effective compound, is also reported.