TABLE 2.

GLGC meta-analysis of genetic loci associated with concentrations of both plasma TG and HDL-C

Locus	Lead traita	Role in lipoprotein metabolism	TG P	HDL P	SNPb
APOA5	TG	Activator of lipoprotein lipase	7 × 10−240	5 × 10−47	rs964184
LPL	TG	Hydrolysis of TG-rich lipoproteins	2 × 10−115	9 × 10−98	rs12678919
MLXIPL	TG	Activation of glycolytic and lipogenic enzymes	9 × 10−59	1 × 10−9	TG rs7811265HDL rs17145738
TRIB1	TG	Unknown	3 × 10−55	6 × 10−19	TG rs2954029HDL rs10808546
APOB	TG	Backbone of atherogenic lipoproteins	1 × 10−45	1 × 10−30	rs1042037
APOE	TG	TG-rich lipoprotein receptor ligand for the LDLR and LDLR-related protein (LRP1)	1 × 10−30	4 × 10−21	TG rs439401HDL rs4420638
FADS	TG	Fatty acid desaturation	5 × 10−24	2 × 10−22	TG rs174546HDL rs174601
PLTP	HDL-C	Transfer phospholipid between TG-rich lipoprotein and HDL	5 × 10−18	2 × 10−22	HDL rs6065906TG rs4810479
GALNT2	HDL-C	O-linked glycosylation of proteins	2 × 10−14	4 × 10−21	HDL rs4846914TG rs1321257
LIPC	HDL-C	TG lipase	2 × 10−13	3 × 10−96	HDL rs1532085TG rs261342
CETP	HDL-C	Exchanges cholesteryl ester for TG between HDL and TG-rich lipoproteins	1 × 10−12	7 × 10−380	HDL rs3764261TG rs7205804
COBLL1	TG	Unknown	2 × 10−10	3 × 10−10	TG rs10195252HDL rs12382675
LRP1	TG	TG-rich lipoprotein receptor via apoE	4 × 10−10	2 × 10−8	TG rs11613352HDL rs3741414
IRS1	HDL-C	Involved in insulin signaling	2 × 10−8	2 × 10−9	HDL rs2972146TG rs2943645
ZNF664	HDL-C	Unknown	1 × 10−8	3 × 10−10	HDL rs4765127TG rs12310367

HDL-C, high-density lipoprotein cholesterol; LDLR, low-density lipoprotein receptor; SNP, single nucleotide polymorphism; TG, triglyceride.

^a“Lead trait” is the strongest associated trait.

^bSNP column is the strongest trait-associated SNP for TG and HDL-C; a single SNP is the strongest associated variant for both traits.