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. 2011 Feb;52(2):245–255. doi: 10.1194/jlr.M011346

Fig. 5.

Fig. 5.

In vivo VLC-PUFA biosynthesis by ELOVL2, ELOVL4, and ELOVL5. The 18:3n-3 and 18:2n-6 PUFAs were obtained from the diet and were subsequently elongated and desaturated by the indicated enzymes into longer PUFAs. ELOVL5 is involved in the elongation of PUFAs up to 22 carbons in length. ELOVL2 elongates from 20:4n-6 and 20:5n-3 series. Specifically, in the testis, ELOVL2 is involved in the biosynthesis of VLC-PUFA (≥C24) up to 30 carbons in length of the n-6 family (gray area). ELOVL4 elongates up to C38 in length. C26FADS, fatty acid desaturase.