Fig. 2.

Salubrinal and SP600125 inhibit PA-induced LOX-1 upregulation in primary mouse macrophages. A: Primary macrophages obtained from mouse peritoneal cavity were stimulated with 200 μM PA for 6 h, and LOX-1 expression was quantified by real-time PCR and normalized relative to 18S rRNA. B: Primary macrophage cells were stimulated with 200 μM PA in the presence or absence of salubrinal (40 μM) or SP600125 (40 μM). After 6 h incubation, cells were harvested and LOX-1 expression was quantified. Data are expressed as means ± SE (n = 3). * P < 0.05, ** P < 0.01 versus PA, ^# P < 0.05 versus Cont.