TABLE 2.

Association of SNPs with TC/HDL-C, LDL-C/HDL-C, and non-HDL-C

					TC/HDL-C		LDL-C/HDL-C		non-HDL-C
SNP	Chr	Gene	Minor allele	MAF (%)	Effect a	P b	Effect a	P b	Effect a	P b
rs4846914	1	GALNT2	A	21	−0.016	0.57	0.006	0.76	0.004	0.86
rs780094	2	GCKR	C	47.7	−0.054	0.02	−0.010	0.56	−0.052	5.0×10−3
rs12654264	5	HMGCR	A	48.3	−0.057	0.01	−0.047	6.8×10−3	−0.086	3.3×10−6
rs17145738	7	MLXIPL	T	10.5	−0.081	0.02	−0.023	0.43	−0.011	0.73
rs326	8	LPL	G	17.6	−0.084	2.8×10−3	−0.029	0.20	−0.021	0.39
rs1800588	15	LIPC	T	36.8	−0.072	6.1×10−4	−0.045	0.01	0.004	0.85
rs3764261	16	CETP	A	14.7	−0.088	2.0×10−3	−0.090	3.1×10−4	0.066	0.01
rs1529729	19	LDLR	C	23	0.003	0.94	−0.007	0.74	0.028	0.21
rs439401	19	APOE cluster	C	40.1	−0.019	0.31	−0.042	0.02	−0.013	0.51
rs4420638	19	APOE cluster	C	11.6	0.134	9.4×10−5	0.119	1.4×10−5	0.116	7.1×10−5

^aEffects were measured as additive effects, which corresponds to the average change in phenotype when the major allele is replaced by the minor allele.

^bP values were calculated using the additive model and adjusted for age, sex, BMI, and diabetes status.