TABLE 3.
Association of candidate SNPs in dyslipidemia and non-dyslipidemia individuals
| Allelic distribution n(%) |
Genotype distribution n(%) |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SNPs | Chr | Gene | Minor allele | Group(s) | R a | C a | R/R a | C/R a | C/C a | P b | OR | 95% CI |
| rs4846914 | 1 | GALNT2 | A | Dyslipidemia | 1086(20.8) | 4142(79.2) | 119(4.6) | 848(32.4) | 1647(63) | |||
| Nondyslipidemia | 657(21.3) | 2421(78.7) | 71(4.6) | 515(33.5) | 953(61.9) | 0.49 | 0.96 | (0.86–1.08) | ||||
| rs780094 | 2 | GCKR | C | Dyslipidemia | 2455(46.8) | 2787(53.2) | 583(22.2) | 1289(49.2) | 749(28.6) | |||
| Nondyslipidemia | 1518(49.4) | 1554(50.6) | 368(24) | 782(50.9) | 386(25.1) | 0.02 | 0.90 | (0.82–0.98) | ||||
| rs12654264 | 5 | HMGCR | A | Dyslipidemia | 2503(48.3) | 2679(51.7) | 630(24.3) | 1243(48) | 718(27.7) | |||
| Nondyslipidemia | 1467(48.1) | 1585(51.9) | 366(24) | 735(48.2) | 425(27.9) | 0.98 | 1.00 | (0.91–1.10) | ||||
| rs17145738 | 7 | MLXIPL | T | Dyslipidemia | 511(9.7) | 4739(90.3) | 19(0.7) | 473(18) | 2133(81.3) | |||
| Nondyslipidemia | 367(11.9) | 2725(88.1) | 23(1.5) | 321(20.8) | 1202(77.7) | 1.1×10−3 | 0.78 | (0.67–0.91) | ||||
| rs326 | 8 | LPL | G | Dyslipidemia | 871(16.7) | 4349(83.3) | 76(2.9) | 719(27.5) | 1815(69.5) | |||
| Nondyslipidemia | 584(19.2) | 2464(80.8) | 58(3.8) | 468(30.7) | 998(65.5) | 0.01 | 0.86 | (0.76–0.96) | ||||
| rs1800588 | 15 | LIPC | T | Dyslipidemia | 1859(35.6) | 3357(64.4) | 335(12.8) | 1189(45.6) | 1084(41.6) | |||
| Nondyslipidemia | 1187(38.8) | 1875(61.2) | 227(14.8) | 733(47.9) | 571(37.3) | 9.8×10−3 | 0.88 | (0.80–0.97) | ||||
| rs3764261 | 16 | CETP | A | Dyslipidemia | 676(13.7) | 4256(86.3) | 53(2.1) | 570(23.1) | 1843(74.7) | |||
| Nondyslipidemia | 471(16.6) | 2373(83.4) | 42(3) | 387(27.2) | 993(69.8) | 4.6×10−4 | 0.79 | (0.69–0.90) | ||||
| rs1529729 | 19 | LDLR | C | Dyslipidemia | 1165(22.2) | 4077(77.8) | 141(5.4) | 883(33.7) | 1597(60.9) | |||
| Nondyslipidemia | 749(24.3) | 2329(75.7) | 86(5.6) | 577(37.5) | 876(56.9) | 0.07 | 0.90 | (0.81–1.01) | ||||
| rs439401 | 19 | APOE cluster | C | Dyslipidemia | 1965(40.6) | 2873(59.4) | 389(16.1) | 1187(49.1) | 843(34.8) | |||
| Nondyslipidemia | 1092(39.1) | 1704(60.9) | 209(14.9) | 674(48.2) | 515(36.8) | 0.11 | 1.08 | (0.98–1.20) | ||||
| rs4420638 | 19 | APOE cluster | C | Dyslipidemia | 616(12.1) | 4480(87.9) | 39(1.5) | 538(21.1) | 1971(77.4) | |||
| Nondyslipidemia | 325(10.8) | 2689(89.2) | 23(1.5) | 279(18.5) | 1205(80) | 0.05 | 1.15 | (0.99–1.33) | ||||
Abbreviations: Chr = chromosome.
a
R/R, homozygous for minor allele; C/R, heterozygous for minor allele; C/C, homozygous for common allele.
b
P values were calculated under the additive model and adjusted for age, sex, BMI and diabetes status.