TABLE 4.
Cumulative effects of the risk factors on TC–HDL-C, TGs and HDL-C
| Variable | Genotype score a | Effect (95% CI) | P value e | |||||
| TC/HDL-C | ||||||||
| Genotype score b | ≤3 | 4 | 5 | 6 | 7 | 8 | ||
| N | 403 | 911 | 1349 | 882 | 163 | 12 | ||
| TC/HDL-C | 3.57(2.97–4.26) | 3.64(3.01–4.36) | 3.80(3.14–4.48) | 3.94(3.25–4.61) | 4.05(3.31–4.67) | 4.14(3.65–4.89) | 0.09 | 9.2×10−11 |
| (0.06∼1.12) | ||||||||
| TG | ||||||||
| Genotype score c | ≤3 | 4 | 5 | 6 | 7 | 8 | ||
| N | 258 | 695 | 1138 | 1079 | 515 | 68 | ||
| Mean TG (mmol/l) | 1.16(0.87–1.59) | 1.3(0.91–1.83) | 1.42(1.01–2.06) | 1.54(1.08–2.19) | 1.50(1.14–2.34) | 1.68(1.19–2.68) | 0.07 | 6.4×10−23 |
| (0.06∼ 0.09) | ||||||||
| High TG (>2.25 mmol/l) n (%) | 30 (11.6) | 108 (15.5) | 219 (19.2) | 245 (22.8) | 137 (26.6) | 24 (35.3) | ||
| HDL-C | ||||||||
| Genotype score d | ≤3 | 4 | 5 | 6 | 7 | 8 | ||
| N | 31 | 144 | 564 | 1155 | 1327 | 587 | ||
| Mean HDL-C (mmol/l) | 1.38 ± 0.41 | 1.30 ± 0.33 | 1.27 ± 0.33 | 1.24 ± 0.31 | 1.19 ± 0.30 | 1.14 ± 0.28 | −0.04 | 4.1×10−23 |
| (−0.05∼−0.04) | ||||||||
| Low HDL-C (<1.03mmol/l) N (%) | 7 (22.6) | 29 (20.1) | 135 (23.9) | 302 (26.1) | 419 (31.6) | 225 (38.3) | ||
a
The genotype score represents the number of risk alleles associated with TC/HDL-C, TG, or HDL-C.
b
Number of risk alleles at the four SNPs: LPL rs326, LIPC rs1800588, CETP rs3764261, APOE cluster rs4420638.
c
Number of risk alleles at the four SNPs: GCKR rs780094, MLXIPL rs17145738, LPL rs326, APOE cluster rs439401.
d
Number of risk alleles at the four SNPs: MLXIPL rs17145738, LPL rs326, LIPC rs1800588, CETP rs3764261.
e
P values were calculated under the additive model and adjusted for age, sex, BMI, and diabetes status.