Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The signaling pathways of JNK in Cr(VI)-exposed skin epidermal cells. Cr(VI) increases intracellular ROS level in JB6 cells. The ROS generated by Cr(VI) contribute to JNK activation. The activated JNK leads to mitochondrial dysfunction and apoptosis. c-Jun, which was activated by JNK, mediates survival signaling through inhibition of p53 activation because of upregulation of SOD expression in Cr(VI)-exposed JB6 cells.
