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. 2010 May 24;1(5):345–355. doi: 10.4161/gmic.1.5.13136

Figure 6.

Figure 6

Histopathology of NZB mice treated with an irrelevant antibody (a) or anti-CD4 (a–h). Tissues fixed in 10% formaldehyde PBS, embedded in paraffin, sectioned 6 µm thick and stained with H&E. Control group: (a) Section of the colon showing normal structures: goblet cells (G) epithelium (EPI), lamina propria (LP), muscularis mucosa (MM), submucosa (SM) and muscular layer (M). ×100. Anti-CD4 group: (b) Section of the colon showing flattened and enlarged epithelial layer with intense chronic inflammatory infiltrates (CI) predominantly in the lamina propria (LP). ×100. (c) Colitis with crypts tortuous (TC) and dilated (DC). The epithelium shows proliferative aspects and lack of goblet cells. ×100. (d) Colitis with areas of intense crypt proliferation showing crypts packed side by side and epithelium with mitotic cells (MI) and dysplastic changes (D). ×400. (e) Colitis with cryptic abscesses (CA). ×400. (f) Colitis with cryptic abscesses sometimes in association with bacteria (B). ×400. (g) Colitis with superficial ulcer (U). ×100. (h) Colitis with deep ulcer (U). The ulcer is covered with cell debris (CD) associated with bacteria (B), the muscular layers were replaced by an abscess. The serosa (S) is thickened, shows edema, congested blood vessels and mononuclear cell infiltrates. ×100.