Table 2.
Differential activity of transcription factorsin two HCC cell lines (SMMC-7721, HCCLM6) with different OPN expression levels (> 2 fold or <0.5-fold change)
| Name | HCCLM6/SMMC-7721 ratio | Description |
|---|---|---|
| Up-regulation | ||
| MAZ | 3.10 | MYC-associated zinc finger protein |
| E4BP4 | 2.86 | nuclear factor, IL- 3 regulated |
| c-Myb | 2.80 | v-myb myeloblastosis viral oncogene |
| GATA-2 | 2.74 | GATA binding protein 2 |
| TEF1 | 2.73 | activator |
| PEBP2 | 2.39 | polyoma enhancer binding protein 2 |
| Smad3/4 | 2.27 | MADH3/4 |
| IRF-1/2 | 2.21 | interferon regulatory factor 1/2 |
| PEBP | 2.13 | polyoma enhancer binding protein |
| GAG | 2.13 | amyloid precursor protin (APP) regulator |
| ADR1 | 2.10 | alcohol dehydrogenase regulatory gene 1 |
| Down-regulation | ||
| NF-E2 | 0.19 | nuclear factor (erythroid-derived 2), 45 kDa |
| EGR | 0.21 | early growth response |
| C/EBPα | 0.22 | CCAAT/enhancer binding protein alpha |
| E2F-1 | 0.28 | E2F transcription factor 1 |
| CYP1A1 | 0.30 | cytochrome P450-c |
| HiNF-A | 0.31 | A nuclear protein |
| Sp1 | 0.31 | Sp1 transcription factor |
| E12/E47 | 0.31 | enhancer binding factors E12/E47 |
| PARP | 0.34 | poly(ADP-ribose) synthetase/polymerase |
| ELK1 | 0.34 | member of ETS oncogene family |
| E4F1 | 0.34 | E4F transcription factor 1 |