Table 1.
Prognostic Clinicopathologic Variables as Predictors for Disease-Specific Survival in 335 NSCLC Patients (Univariate Analyses; Log-rank Test).
| Characteristic | Patients (n) | Patients (%) | Median survival (months) | 5-Year survival (%) | P |
|---|---|---|---|---|---|
| Age | 0.34 | ||||
| ≤65 years | 156 | 47 | 83 | 55 | |
| >65 years | 179 | 53 | NR | 60 | |
| Sex | 0.20 | ||||
| Female | 82 | 25 | 190 | 63 | |
| Male | 253 | 75 | 83 | 56 | |
| Smoking | 0.23 | ||||
| Never | 15 | 5 | 19 | 43 | |
| Current | 215 | 64 | NR | 60 | |
| Former | 105 | 31 | 71 | 54 | |
| Performance status | 0.013 | ||||
| ECOG 0 | 197 | 59 | NR | 63 | |
| ECOG 1 | 120 | 36 | 64 | 52 | |
| ECOG 2 | 18 | 5 | 25 | 33 | |
| Weight loss | 0.71 | ||||
| <10% | 303 | 90 | 127 | 58 | |
| >10% | 32 | 10 | 98 | 57 | |
| Histology | 0.028 | ||||
| SCC | 191 | 57 | NR | 66 | |
| Adenocarcinoma | 95 | 34 | 47 | 41 | |
| LCC | 31 | 9 | 98 | 56 | |
| BAC | 18 | NR | 71 | ||
| Differentiation | <0.001 | ||||
| Poor | 138 | 41 | 47 | 47 | |
| Moderate | 144 | 43 | 190 | 64 | |
| Well | 53 | 16 | NR | 68 | |
| Surgical procedure | 0.004 | ||||
| Lobectomy + Wedge* | 243 | 73 | 190 | 61 | |
| Pneumonectomy | 92 | 27 | 37 | 47 | |
| Pathological stage | <0.001 | ||||
| I | 157 | 47 | 190 | 71 | |
| II | 136 | 41 | 61 | 51 | |
| IIIa | 42 | 12 | 17 | 23 | |
| Tumor status | <0.001 | ||||
| 1 | 85 | 25 | 190 | 74 | |
| 2 | 188 | 56 | 84 | 57 | |
| 3 | 62 | 19 | 25 | 36 | |
| Nodal status | <0.001 | ||||
| 0 | 232 | 69 | 190 | 66 | |
| 1 | 76 | 23 | 35 | 43 | |
| 2 | 27 | 8 | 18 | 18 | |
| Surgical margins | 0.29 | ||||
| Free | 307 | 92 | 190 | 58 | |
| Not free | 28 | 8 | 47 | 47 | |
| Vascular infiltration | <0.001 | ||||
| No | 284 | 85 | 190 | 58 | |
| Yes | 51 | 15 | 27 | 32 |
NR, not reached
* Wedge, n = 10
Abbreviations: SCC; squamous cell carcinoma; LCC, large-cell carcinoma; BAC, bronchioalveolar carcinoma