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Promoter methylation is a plausible mechanism of EBV-mediated dysregulation of multiple genes. Bisulfite sequencing reveals methylation patterns of five genes: A) CDKN2A (p16), B) ID4, C) COX2, D) ICAM1, and E) TFF1. Methylation patterns are shown for several clones of each gene with or without EBV infection, and with or without 5-aza-2'-deoxycytidine (aza) treatment. In each clone, methylated sites are dark red ovals whereas unmethylated sites are light blue ovals.
