Figure 5.

sVEGFR2 is a sensitive biomarker for sunitinib treatment but fails to predict clinical response. A) In 16 patients, repeated sVEGFR2 measurements were performed on days 1 - 70. sVEGFR2 declines significantly during treatment with sunitinib (day 28: P < 0.0001). B) Patients were grouped according to PFS above or below the median. Compared to baseline, sVEGFR2 decreased in each group significantly on day 28 [P < 0.0001 (below median), P = 0.0048 (above median), respectively]. However, no difference was shown at day 28 between both groups (P = 3760).