Table 2.
Genotypes, haplotypes and diplotypes distribution of IGFBP5 polymorphisms in SCCHN cases and cancer-free controls
| SNP/Haplotype/Diplotype | Cases No. (%) |
Controls No. (%) |
P value | Crude OR (95% CI) |
Adjusted OR (95% CI)* |
|---|---|---|---|---|---|
| All subjects | 1082 (100) | 1120 (100) | |||
| Genotypes | |||||
| -1195T>C (rs1978346) | 0.797† | ||||
| TT | 461 (42.6) | 466 (41.6) | 1.00 | 1.00 | |
| CT | 486 (44.9) | 519 (46.3) | 0.95 (0.79-1.13) | 0.98 (0.81-1.18) | |
| CC | 135 (12.5) | 135 (12.1) | 1.01 (0.77-1.33) | 1.11 (0.84-1.47) | |
| CT+CC | 621 (57.4) | 654 (58.4) | 0.635‡ | 0.96 (0.81-1.14) | 1.01 (0.84-1.20) |
| -709G>C (rs4480966) | 0.199† | ||||
| GG | 828 (76.5) | 862 (77.0) | 1.00 | 1.00 | |
| CG | 239 (22.1) | 251 (22.4) | 0.99 (0.81-1.21) | 1.05 (0.85-1.29) | |
| CC | 15 (1.4) | 7 (0.6) | 2.23 (0.91-5.50) | 2.10 (0.83-5.31) | |
| CG+CC | 254 (23.5) | 258 (23.0) | 0.807‡ | 1.03 (0.84-1.25) | 1.08 (0.88-1.33) |
| Haplotypes§ | 0.835# | ||||
| T-G | 1405 (64.9) | 1449 (64.7) | 1.00 | 1.00 | |
| C-G | 490 (22.6) | 526 (23.5) | 0.96 (0.84-1.11) | 1.00 (0.86-1.16) | |
| C-C | 266 (12.3) | 263 (11.7) | 1.05 (0.86-1.26) | 1.10 (0.90-1.34) | |
| T-C | 3 (0.1) | 2 (0.1) | 1.50 (0.25-9.00) | 1.64 (0.24-11.28) | |
| Diplotypes | 0.581# | ||||
| T-G/T-G | 458 (42.3) | 464 (41.4) | 1.00 | 1.00 | |
| C-G/T-G | 308 (28.5) | 330 (29.5) | 0.95 (0.77-1.16) | 0.97 (0.79-1.20) | |
| C-C/T-G | 178 (16.5) | 189 (16.9) | 0.95 (0.77-1.22) | 1.00 (0.78-1.29) | |
| C-G/C-G | 62 (5.7) | 68 (6.1) | 0.92 (0.64-1.33) | 0.99 (0.68-1.46) | |
| C-C/C-G | 58 (5.4) | 60 (5.4) | 0.98 (0.67-1.44) | 1.13 (0.76-1.69) | |
| Others‖ | 18 (1.7) | 9 (0.8) | 2.03 (0.90-4.56) | 1.99 (0.86-4.61) |
*
Adjusted for age, sex, smoking and alcohol status in the logistic regression model.
†
Distribution of three genotypes
‡
Distribution of combined genotypes
§
The number for cases and controls in Haplotype analysis is chromosome number.
‖
Includes 2 minor diplotypes, each with a frequency < 0.05.
#
χ2 tests for the difference of haplotypes and diplotypes frequencies distributions between cases and controls