Table 5.
Genotypes, haplotypes and diplotypes distribution of IGFBP5 polymorphisms associated with high TNM stage among patients with SCCHN at HPV-unrelated sites (oral cavity and larynx/hypopharynx only)
| SNP position | Stages I,II No. (%) |
Stages III, IV No. (%) |
P value | Crude OR (95% CI) |
Adjusted OR (95% CI)* |
|---|---|---|---|---|---|
| All subjects | 226 (100%) | 304 (100%) | |||
| Genotypes | |||||
| -1195T>C (rs1978346) | 0.018† | ||||
| TT | 118 (52.2) | 128 (42.1) | 1.00 | 1.00 | |
| CT | 89 (39.4) | 130 (42.8) | 1.35 (0.93-1.95) | 1.25 (0.85-1.85) | |
| CC | 19 (8.4) | 46 (15.1) | 2.23 (1.24-4.03) | 2.21 (1.19-4.11) | |
| P, Trend | 0.014§ | ||||
| CT+CC | 128 (42.1) | 176 (57.9) | 0.021‡ | 1.50 (1.06-2.12) | 1.42 (0.99-2.04) |
| -709G>C (rs4480966) | 0.689† | ||||
| GG | 181 (80.1) | 235 (77.3) | 1.00 | 1.00 | |
| CG | 42 (18.6) | 63 (20.7) | 1.16 (0.75-1.79) | 1.09 (0.69-1.72) | |
| CC | 3 (1.3) | 6 (2.0) | 1.54 (0.38-6.24) | 1.40 (0.34-5.80) | |
| P, Trend | 0.592§ | ||||
| CG+CC | 45 (19.9) | 69 (22.7) | 0.440‡ | 1.18 (0.77-1.80) | 1.11 (0.71-1.73) |
| Haplotypes‖ | 0.020†† | ||||
| T-G | 324 (71.7) | 386 (63.5) | 1.00 | 1.00 | |
| C-G | 80 (17.7) | 147 (24.2) | 1.50 (1.09-2.05) | 1.48 (1.06-2.07) | |
| C-C | 47 (10.4) | 75 (12.3) | 1.37 (0.80-2.35) | 1.31 (0.75-2.28) | |
| T-C | 1 (0.2) | 0 (0) | NA | NA | |
| Diplotypes | 0.163†† | ||||
| T-G/T-G | 117 (51.8) | 128 (42.1) | 1.00 | 1.00 | |
| C-G/T-G | 57 (25.2) | 87 (28.6) | 1.40 (0.92-2.12) | 1.31 (0.84-2.04) | |
| C-C/T-G | 32 (14.2) | 43 (14.1) | 1.23 (0.73-2.08) | 1.13 (0.65-1.95) | |
| C-C/C-G | 9 (4.0) | 20 (6.6) | 2.03 (0.89-4.64) | 1.91 (0.81-4.51) | |
| C-G/C-G | 7 (3.1) | 20 (6.6) | 2.61 (1.07-6.40) | 2.90 (1.10-7.64) | |
| Others** | 4 (1.8) | 6 (2.0) | 1.37 (0.38-4.98) | 1.29 (0.35-4.78) |
*
Adjusted for age, sex, smoking and alcohol status, education level, and income level in the logistic regression model.
†
Distribution of three genotypes
‡
Distribution of combined genotypes
§
P trend was tested according to the distribution of tumor stages over 3 genotypes
‖
The number for cases and controls in Haplotype analysis is chromosome number.
**
Includes 2 minor diplotypes, each with a frequency < 0.05.
††
χ2 tests for the difference of haplotypes and diplotypes frequencies distributions between cases and controls