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IC50 values* (μM) for triterpenes using human intestinal microsomes (HIM) or recombinant cytochrome P450 3A4 (rCYP3A4) as the enzyme source. Ketoconazole (1 μM) was used as a positive control for CYP3A inhibition and inhibited activity by >90%.
| Compound | HIM | rCYP3A4 |
|---|---|---|
| Ursolic acid (1) | <10 | <10 |
| Maslinic acid (2) | 7.4 ± 0.5 | 2.8 ± 0.2 |
| Corosolic acid (3) | 8.8 ± 0.9 | 4.3 ± 0.3 |
Values denote means ± SEs of parameter estimates.
