Table 4.

Analysis of correlation between change in circulating inflammatory cells and blood plasma/progenitor cell biomarkers at day 14 after sunitinib treatment (Kendall's τβ with 95% CI)

Kendall's τβ	WBCs	Lymphocytes	Monocytes	Platelets	Neutrophils
sVEGFR1	−0.09 [−0.37,0.18]	−0.34 [−0.55,−0.13]	−0.13 [−0.45,0.18]	−0.03 [−0.28,0.21]	−0.07 [−0.31,0.18]
P value	0.48	0.0075	0.32	0.8	0.62
sVEGFR2	−0.32 [−0.54,−0.10]	−0.12 [−0.37,0.14]	−0.26 [−0.57,0.04]	0.04 [−0.30,0.38]	−0.43 [−0.62,−0.24]
P value	0.02	0.41	0.055	0.8	0.0013
IL-1β	−0.31 [−0.53,−0.09]	−0.11 [−0.34,0.11]	−0.07 [−0.31,0.18]	0.05 [−0.20,0.31]	−0.23 [−0.42,−0.04]
P value	0.022	0.43	0.65	0.71	0.096
IL-6	0.07 [−0.15,0.30]	−0.08 [−0.40,0.25]	0.23 [−0.02,0.48]	0.05 [−0.26,0.37]	0.21 [−0.04,0.47]
P value	0.59	0.59	0.096	0.71	0.12
IL-8	−0.27 [−0.51,0.02]	0.05 [−0.22,0.32]	−0.07 [−0.33,0.19]	0.01 [−0.31,0.33]	−0.30 [−0.55,−0.05]
P value	0.058	0.73	0.63	0.97	0.033
TNF-α	−0.41 [−0.64,−0.18]	−0.24 [−0.52,0.03]	−0.08 [−0.35,0.19]	−0.03 [−0.28,0.22]	−0.34 [−0.60,−0.08]
P value	0.0027	0.08	0.56	0.84	0.013
sVEGFR3	−0.08 [−0.41,0.24]	−0.30 [−0.57,−0.04]	−0.05 [−0.27,0.17]	−0.32 [−0.59,0.06]	0.13 [−0.20,0.47]
P value	0.61	0.056	0.77	0.042	0.42
VEGF-C	−0.17 [−0.42,0.08]	0.00 [−0.26,0.26]	−0.02 [−0.28,0.24]	0.30 [0.08,0.52]	−0.24 [−0.49,0.00]
P value	0.2	1	0.89	0.025	0.069

Data are shown as Kendall's τβ with approximate 95% confidence intervals between ratios of day 14 to baseline ratios of biomarkers levels, with P-value from Kendall's test.