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. Author manuscript; available in PMC: 2011 Jan 20.
Published in final edited form as: J Immunol. 2009 May 15;182(10):6129–6135. doi: 10.4049/jimmunol.0804226

FIGURE 1.

FIGURE 1

Reduced helper activity of aged naive T cells can be enhanced with TLR-binding adjuvant. Young or aged TCR Tg CD4 T cells (1 × 106) were transferred into young CD4KO hosts which were then immunized i.p. with 200 µg of NP-PCC/alum alone (A) or with poly(I:C) (50 µg; B). The number of NP-specific cells and GC cells (CD38lowPNAhigh) in the spleen on day 14 was determined by flow cytometry using NP-allophycocyanin. Results shown are mean ± SE from a representative experiment. *, p < 0.05 by Student’s t test.