Table 2.
Alignments of H6PD missense variants and their vicinity amino acids from 12 species
| I402V | D151A | G359D* | R453Q | N484D | P554L | Accession No. |
|
|---|---|---|---|---|---|---|---|
| Human | FHIGHG | FAYEDIA | SGKALD | PVRERDA | SWNFWTP | SPLVSAW | NP_004276 |
| Rhesus monkeys | FHIGHG | FAYADIA | SGKALD | PVQERDA | SWGFWTP | SPLVSAW | XP_001099298 |
| Horse | FYIGHG | FAYADIA | SGKALD | PVREQDA | SWVFWTP | SPLISAW | XP_001490983 |
| Dog | FYIGHG | FAYADIA | SGKALD | PVREQDA | SWVFWTP | SPLISAW | XP_546762 |
| Cow | FYIGHG | FAYVDIA | SGKALD | PVREQDA | SWVFWTP | SPLISAW | XP_615112 |
| Rat | FYIGHG | FAYADIA | SGKALD | PVREQDA | SWVFWTP | SPLITAW | NP_001100168 |
| Mouse | FYIGHG | FAYADIA | SGKALD | PVREQDA | SWVFWTP | SPLITAW | NP_775547 |
| Rabbit | FYIGHG | FAYADIA | SGKALD | PVKERDA | SWVFWTP | SPLISAW | A47563 |
| Frog | FHIGHG | FTYTDIA | SGKALD | PVQEMDA | SWKFWTP | ADMVSAW | NP_001106505 |
| Opossum | FYIGHG | FAYAGIA | SGKALD | PRQERDA | SWDVWTP | SPLVSAW | XP_001362573 |
| Chicken | FYIGHG | FAYTEIA | SGKALD | PVKERDA | SWAFWTP | SPLVSAW | XP_425746 |
| Zebra Finch | FYFGHG | FAYTEIA | SGKALD | PVRERDA | SWAFWTP | NSMVSNW | XP_002187325 |
The locations of human H6PD variants are bold and underlined. Bold letters refer to the amino acids of each species that different from the human variant at the corresponding site.
A missense mutation causes CRD [10].