Table 2. Summary of the studies included in the systematic review investigating the effect of -arginine administration on mechanical focal cerebral ischemia.

Study	Species	Model	Duration of ischemia (minutes)	Dose -arginine (mg/kg)	Timing of -arginine	Route	Timing of death (hours)	STAIR score
Buisson et al (1993)	SD rats	Cautery	Permanent	300	+5 minutes to +3 hours	IP	48	2
Escott et al (1998)	SD rats	Filament	120	300	+5 minutes	IP	24	4
He et al (1995)	SH rats	Ligation	Permanent	300 IP then 200 IV	−20 minutes to +1 hour	IP and IV	24	2
Iadecola et al (1995a, 1995b)	SH rats	Cautery	Permanent	300	+24 hours to +96 hours	IP	96	3
Morikawa et al (1992a, 1992b)	SH rats	Ligation and cautery	Permanent	300	−16 hours to +2 hours	IP	24	2
Morikawa et al (1994)	SD and SH rats	Cautery	Permanent	300	+5 minutes to 1 hour	IV and IP	24	2
Temiz et al (2003)	NZ rabbits	Ligation	Permanent	2.5, 7.5, 12.5	0 hour	IV	6	5
Zhang et al (1996a)	SD rats	Filament	120	300	+24 hours to +96 hours	IP	96	3
Zhang et al (2004a)	SD rats	Filament	60, 180, 360	500	+ 2 hours or +3 hours	IP	Not stated	3
Zhao et al (2003)	C57BL/6 mice	Cautery	Permanent	300	+12 hours to +96 hours	IP	96	2

IP, intraperitoneal; IV, intravenous; SD, Sprague Dawley; SH, spontaneously hypertensive; STAIR, Stroke Therapy Academic Industry Roundtable; NZ, New Zealand.

Timings are reported relative to the onset of ischemia.