Table 2. Summary of the studies included in the systematic review investigating the effect of -arginine administration on mechanical focal cerebral ischemia.
Study | Species | Model | Duration of ischemia (minutes) | Dose -arginine (mg/kg) | Timing of -arginine | Route | Timing of death (hours) | STAIR score |
---|---|---|---|---|---|---|---|---|
Buisson et al (1993) | SD rats | Cautery | Permanent | 300 | +5 minutes to +3 hours | IP | 48 | 2 |
Escott et al (1998) | SD rats | Filament | 120 | 300 | +5 minutes | IP | 24 | 4 |
He et al (1995) | SH rats | Ligation | Permanent | 300 IP then 200 IV | −20 minutes to +1 hour | IP and IV | 24 | 2 |
Iadecola et al (1995a, 1995b) | SH rats | Cautery | Permanent | 300 | +24 hours to +96 hours | IP | 96 | 3 |
Morikawa et al (1992a, 1992b) | SH rats | Ligation and cautery | Permanent | 300 | −16 hours to +2 hours | IP | 24 | 2 |
Morikawa et al (1994) | SD and SH rats | Cautery | Permanent | 300 | +5 minutes to 1 hour | IV and IP | 24 | 2 |
Temiz et al (2003) | NZ rabbits | Ligation | Permanent | 2.5, 7.5, 12.5 | 0 hour | IV | 6 | 5 |
Zhang et al (1996a) | SD rats | Filament | 120 | 300 | +24 hours to +96 hours | IP | 96 | 3 |
Zhang et al (2004a) | SD rats | Filament | 60, 180, 360 | 500 | + 2 hours or +3 hours | IP | Not stated | 3 |
Zhao et al (2003) | C57BL/6 mice | Cautery | Permanent | 300 | +12 hours to +96 hours | IP | 96 | 2 |
IP, intraperitoneal; IV, intravenous; SD, Sprague Dawley; SH, spontaneously hypertensive; STAIR, Stroke Therapy Academic Industry Roundtable; NZ, New Zealand.
Timings are reported relative to the onset of ischemia.