Figure 1.

Platelet activation associates with cognitive decline in Alzheimer's disease (AD). (A) Box plot showing platelet GPIIb–IIIa complex activation and P-selectin expression levels in AD patients with fast versus slow cognitive decline defined after a 1-year follow-up period. (B) Correlation between change of MMSE score (one year after baseline) and platelet GPIIb–IIIa activation (n=40; r=−0.573; P<0.001) and P-selectin expression (n=40; r=−0.411; P=0.009) in AD patients. (C) Receiver operating characteristic curve for platelet GPIIb–IIIa activation and P-selectin expression for fast cognitive decline after 1-year follow-up in AD patients. GPIIb–IIIa, glycoprotein IIb–IIIa; MMSE, Mini-Mental State Examination.