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. 2011 Jan;18(1):24–38. doi: 10.1101/lm.1980211

Figure 8.

Figure 8.

The effect of EGR-1 knockdown on auditory fear memory reconsolidation is temporally graded. (A) Schematic of the behavioral paradigm. Rats were trained followed 24 h later by a tone reactivation session in a distinct context. Rats were then given intra-LA infusion of either antisense (n = 3) or scrambled (n = 4) ODN (250 pmol; 1 µL/side) 6 h later. Auditory fear memory was assessed 24 h after reactivation (18 h after infusion). (B) Post-shock freezing scores in each group immediately after the conditioning trials. (C) Memory reactivation scores in each group during the tone reactivation trial. (D) Auditory fear memory assessed 18 h after infusions for both antisense and scrambled groups across all 10 tone presentations. (E) Histological verification of cannula placements for rats infused with EGR-1 antisense (○) or EGR-1 scrambled ODN (•). Panels adapted from Paxinos and Watson (1998) and reprinted with permission from Elsevier © 1998.