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. 2011 Jan;18(1):1–10. doi: 10.1101/lm.1923211

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Figure 2. — Yohimbine treatment enhances extinction. (A) Mean lever presses per stimulus for the initial extinction sessions. (B) Mean lever presses per stimulus during the final extinction session containing the drug treatments and during the test session conducted drug-free 4 wk later. Treatment with yohimbine during extinction had no effect on responding (F_(2,27) < 1); however, when rats were tested for spontaneous recovery 4 wk later, while rats previously treated with saline showed a significant increase in responding (F_(1,9) = 7.0, P < 0.05), those treated with yohimbine did not (1.25 mg/kg; F_(1,9) = 1.8, P > 0.05; 2.5 mg/kg; F_(1,9) = 1.4, P > 0.05), indicating that yohimbine treatment enhanced extinction of an appetitive stimulus. *Indicates a significant difference in the number of lever presses; P < 0.05. N = 10 per group.