Table 3.
Association between short term use of NSAIDs and risk of Parkinson’s disease in cases and matched controls from the Physicians’ Health Study
| Days of use in prior year | Odds ratio (95% CI)* | |
|---|---|---|
| At index date | 5 years prior† | |
| Controls matched by age | ||
| Non-aspirin NSAID use: | ||
| None | 1.00 | 1.00 |
| 1–14 | 0.84 (0.65 to 1.08) | 1.11 (0.87 to 1.43) |
| 15–60 | 0.87 (0.64 to 1.18) | 1.15 (0.86 to 1.55) |
| >60 | 1.10 (0.81 to 1.50) | 1.09 (0.76 to 1.55) |
| Aspirin use: | ||
| None | 1.00 | 1.00 |
| 1–14 | 0.82 (0.56 to 1.18) | 0.96 (0.66 to 1.41) |
| 15–60 | 1.15 (0.76 to 1.76) | 1.12 (0.71 to 1.78) |
| >60 | 0.92 (0.74 to 1.14) | 0.93 (0.73 to 1.18) |
| Controls matched by age and confounder scores‡ | ||
| Non-aspirin NSAID use: | ||
| None | 1.00 | 1.00 |
| 1–14 | 0.82 (0.63 to 1.07) | 1.05 (0.81 to 1.37) |
| 15–60 | 0.71 (0.51 to 0.99) | 1.05 (0.76 to 1.45) |
| >60 | 0.82 (0.59 to 1.14) | 0.66 (0.44 to 1.00) |
| Aspirin use: | ||
| None | 1.00 | 1.00 |
| 1–14 | 0.90 (0.60 to 1.34) | 0.98 (0.64 to 1.48) |
| 15–60 | 1.29 (0.81 to 2.05) | 1.23 (0.75 to 2.02) |
| >60 | 0.99 (0.78 to 1.26) | 0.98 (0.75 to 1.28) |
*Estimated by conditional logistic regression. Analyses were adjusted for the following variables at time of matching: smoking (never, past, current), alcohol (daily, weekly, monthly), body mass index (<25, 25–<30, ≥30), exercise to sweat (ever v never). We adjusted for aspirin use when estimating effects of non-aspirin NSAIDS and vice versa.
†Excluding drug use within 5 years before the index date.
‡Confounder scores=modified Charlson comorbidity score, score for indicators of NSAID use, and score for NSAID side effects.