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. Author manuscript; available in PMC: 2012 Jan 20.
Published in final edited form as: Cell Host Microbe. 2011 Jan 20;9(1):46–57. doi: 10.1016/j.chom.2010.12.005

Figure 2. The compensatory changes in SIV ΔnefP enhance virus replication in interferon-treated rhesus macaque lymphocytes.

Figure 2

Activated primary rhesus macaque lymphocytes were infected with wild-type SIV, SIV Δnef and SIV ΔnefP. On day two post-infection, the cultures were divided and maintained in medium with or without IFNα. (A) The upregulation of tetherin on CD4+ lymphocytes was verified by flow cytometry 24 hours after treatment with IFNα. Virus replication was monitored by the accumulation of p27 in the supernatant for cultures maintained without (B, D and F), or with (C, E and G), 100 U/ml IFNα.