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. Author manuscript; available in PMC: 2011 Jan 20.
Published in final edited form as: Trends Neurosci. 2010 Sep 16;33(11):493–502. doi: 10.1016/j.tins.2010.07.004

Table 2.

Neural features of palmitoylation

Protein targets Protein family Palmitoylating enzyme Physiological/pathophysiological relevance Refs
β2-adrenergic receptor G-protein coupled receptor ND Regulates phosphorylation and internalization of β-arrestin [66]
CDC42 Small GTPase ND Neurite outgrowth and dendritic spine formation [60,62]
GABAAR (γ2 subunit) Neurotransmitter DHHC 3,7 Inhibition of synaptic transmission [76]
AMPAR (GluR1, GluR2 subunits) Ion channel DHHC 3 Regulates AMPAR surface expression [69]
Gαq, Gαs G-protein signaling DHHC 7 Regulates G-protein assembly and activity [64,65]
Huntingtin Polyglutamine DHHC 17 Huntington’s disease [83]
NMDAR Neurotransmitter receptor ND Enhances tyrosine phosphorylation and increases surface expression [68]
PSD95 Scaffolding protein DHHC 2, 15, 3, 7 Synaptic targeting and postsynaptic protein assembly [71]
SNAP25 Vesicle trafficking DHHC 17 Neurotransmitter release, Huntington’s disease [59]
Synaptobrevin Vesicle trafficking ND Multimerization of synaptobrevin [60]

GABAAR, gamma-aminobutyric acid receptor; DHHC, aspartate-histidine-histidine-cysteine; NMDAR, N-methyl-D-aspartate receptor; PSD95, postsynaptic density protein 95; SNAP25, synaptosomal-associated protein 25; CDC42, cell division control protein 42; AMPAR, α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptor; ND, not determined.