Table 5.

Functional changes in nonfluent PPA patients

Contrast and brain region	MNI coordinates			Volume (mm3)	Max t	p
	x	y	z
Modulated by syntactic complexity less in nonfluent PPA than in controls
Left dorsal posterior IFG and IFS	−44	21	25	1680	4.03	0.014†
Right dorsal posterior IFG and IFS	47	26	16	1336	5.87	0.027†
Modulated by reaction time less in nonfluent PPA than in controls
Left IFG/S and precentral gyrus	−39	5	38	4072	4.07	0.007
Activated relative to rest more in nonfluent PPA than in controls
Left anterior IFG (pars triangularis and orbitalis)	−46	25	6	5664	6.17	0.003
Activated more in nonfluent PPA than controls, accuracy and reaction time matched
Left anterior IFG (pars triangularis and orbitalis)	−48	25	8	2560	6.34	0.045

^†Search volume restricted to the set of regions activated in normal controls.