Table 4.

Multivariate odds ratios (OR) and 95% confidence intervals for the association of distal colorectal cancer with DNA methylation-related nutrients, by race (North Carolina Colon Cancer Study-Phase II, 2001–2006)

Nutrient quartiles	Median intake/day in controls	Whites (n = 1,520)			African Americans (n = 384)
		No. of cases	OR	95% CI	No. of cases	OR	95% CI
Folate (μg) (food only)a
Q1	272	188	1.00		55	1.00
Q2	372	189	0.82	0.60–1.10	42	0.65	0.35–1.22
Q3	484	177	0.61	0.45–0.84	43	0.88	0.45–1.73
Q4	641	166	0.50	0.36–0.69	85	1.08	0.58–2.00
P for linear trend			<0.0001			0.62
Folate (μg) (food + supplements)b
Q1	321	193	1.00		55	1.00
Q2	531	195	0.67	0.49–0.93	53	0.87	0.49–1.54
Q3	753	167	0.78	0.58–1.05	56	2.71	1.41–5.20
Q4	961	165	0.62	0.45–0.86	61	1.59	0.72–3.25
P for linear trend			0.01			0.01
Vitamin B6 (mg) (food only)c
Q1	1.3	179	1.00		49	1.00
Q2	1.8	184	0.80	0.591.08	42	1.12	0.61–2.04
Q3	2.3	211	0.69	0.51–0.94	53	1.38	0.73–2.60
Q4	3.1	146	0.48	0.35–0.67	81	1.53	0.81–2.91
P for linear trend			<0.0001			0.16
Vitamin B6 (mg) (food + supplements)d
Q1	1.5	192	1.00		54	1.00
Q2	2.6	206	0.78	0.57–1.07	59	1.09	0.62–1.91
Q3	3.8	172	0.91	0.67–1.23	59	1.65	0.87–3.13
Q4	5.1	150	0.55	0.40–0.77	53	1.93	0.90–4.14
P for linear trend			0.003			0.04
Vitamin B12 (μg) (food only)e
Q1	2.5	183	1.00		52	1.00
Q2	4.3	209	0.98	0.72–1.32	50	1.40	0.74–2.62
Q3	6.2	179	0.66	0.48–0.90	50	1.27	0.62–2.61
Q4	9.5	149	0.59	0.42–0.81	73	0.79	0.44–1.42
P for linear trend			0.0002			0.30
Vitamin B12 (μg) (food + supplements)f
Q1	3.3	207	1.00		55	1.00
Q2	6.9	183	0.86	0.63–1.16	61	0.89	0.49–1.60
Q3	9.8	185	0.91	0.67–1.23	43	1.56	0.81–3.02
Q4	13.5	145	0.61	0.44–0.84	66	1.13	0.59–2.15
P for linear trend			0.005			0.41
All DNA methylation-related nutrients (mg) (food + supplements)g
Q1	1.9	190	1.00		52	1.00
Q2	3.2	208	0.81	0.60–1.11	59	0.96	0.55–1.69
Q3	4.6	169	0.90	0.66–1.21	62	1.68	0.89–3.16
Q4	6.2	153	0.57	0.41–0.80	52	1.66	0.77–3.58
P for linear trend			0.003			0.07

Adjusted for age, sex, education, BMI, family history of CRC, non-steroidal anti-inflammatory drug use, and total energy

^aCutoffs for men: 358, 460, and 585 μg; cutoffs for women: 292, 368, and 466 μg

^bCutoffs for men: 456, 675, 864 μg; cutoffs for women: 361, 610, and 790 μg

^cCutoffs for men: 1.7, 2.2, 2.8 mg; cutoffs for women: 1.3, 1.7, and 2.3 mg

^dCutoffs for men: 2.2, 3.4, and 4.4 mg; cutoffs for women: 1.8, 3.2, and 4.1 mg

^eCutoffs for men: 4.0, 5.8, and 8.2 μg; cutoffs for women: 2.7, 4.0, 5.6 μg

^fCutoffs for men: 5.6, 9.3, and 12.1 μg; cutoffs for women: 4.2, 7.9, and 10.2 μg

^gCutoffs for men: 2.6, 4.1, and 5.3 mg; cutoffs for women: 2.2, 3.8, and 5.0 mg