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. 2010 Dec 8;20(4):806–819. doi: 10.1093/hmg/ddq524

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Figure 6. — Art-P70/p53 tumors harbor clonal chromosomal translocations. (A) Table summarizing clonal translocations observed in Art-P70/p53 tumors. Metaphases from primary tumor cells or early passage tumor cell cultures were analyzed by SKY. At least 10 metaphases from each tumor were scored. (B) SKY images of metaphase chromosomes from Art-P70/p53 tumors. DAPI staining (left panels) and SKY analysis (right panels) of tumor C325 and C227 containing clonal t(4;14) and t(6;13) translocations, respectively. Arrows indicate translocated chromosomes. (C) FISH analyses of metaphases from Art-P70/p53 tumors. Representative FISH analyses of metaphases from Art-P70/p53 tumors. Left panel, pro-B lymphoma, C219. Left panel, thymic tumor C306. At least 20 metaphases were scored for each tumor. Diagrams indicate the relative chromosomal positions and fluorescent colors of BAC probes. Inset, enlarged images of co-localized probes.