Table 1.

Functional novelty of structures.

Annotations and period	Source	First structures	Structures		% first
			total	nr	total	nr
GO terms during PSI	MCSG	45	1165	1110	3.86	4.05
	JCSG	33	987	938	3.34	3.52
	NESG	23	808	720	2.85	3.19
	NYSGXRC	35	883	789	3.96	4.44
	PSI	153	4101	3711	3.73	4.12
	Non-PSI	1677	49373	22192	3.40	7.56
GO terms during PSI-1	MCSG	25	274	265	9.12	9.43
	JCSG	18	181	169	9.94	10.65
	NESG	15	178	170	8.43	8.82
	NYSGXRC	19	187	169	10.16	11.24
	PSI	82	872	811	9.40	10.11
	Non-PSI	1189	20803	10319	5.72	11.52
GO terms during PSI-2	MCSG	20	891	852	2.24	2.35
	JCSG	15	806	772	1.86	1.94
	NESG	8	630	558	1.27	1.43
	NYSGXRC	16	696	624	2.30	2.56
	PSI	71	3229	2964	2.20	2.40
	Non-PSI	488	28570	14975	1.57	3.26
Pfam families during PSI	MCSG	241	1165	1110	20.69	21.71
	JCSG	133	987	938	13.48	14.18
	NESG	197	808	720	24.38	27.36
	NYSGXRC	131	883	789	14.84	16.60
	PSI	726	4101	3711	17.70	19.56
	Non-PSI	3028	49373	22192	6.13	13.64
Pfam families during PSI-1	MCSG	108	274	265	39.42	40.75
	JCSG	36	181	169	19.89	21.30
	NESG	69	178	170	38.76	40.59
	NYSGXRC	35	187	169	18.72	20.71
	PSI	260	872	811	29.82	32.06
	Non-PSI	2069	20803	10319	9.95	20.05
Pfam families during PSI-2	MCSG	133	891	852	14.93	15.61
	JCSG	97	806	772	12.03	12.56
	NESG	128	630	558	20.32	22.94
	NYSGXRC	96	696	624	13.79	15.38
	PSI	466	3229	2964	14.43	15.72
	Non-PSI	959	28570	14975	3.36	6.40

Numbers of first structures and their percentage of total structures and non-redundant (nr) structures at 95% sequence identity for molecular function GO terms and Pfam families during PSI, PSI-1, and PSI-2.