Figure 7.

Phylogenetic tree of PIK3/4III and related protein kinases with IC₅₀ values from tested inhibitors. Compound names in column are as reported by Knight et al. [31] (bold font) and Apsel et al. [32] (italics). Kinase assay are aligned with their branching order in the phylogenetic tree. IC₅₀ values (μM) are shaded according to potency with smaller values being more effective inhibitors of kinase activity. The tree was constructed using the neighbor-joining method as described for Figure 2 with numbers at nodes showing percent support in 1000 bootstrap replications.