Table 1.
Cytokine response
| Macrosphere model | Human stroke | tMCAO | |
|---|---|---|---|
| Activation of microglia (maximum) | day 3 (day 7) | day 3 (day 7)37 | 6 h (day 3)17 |
| Transformation from ramified to ameboid microglia in the infarct border | from day 3 on | days? | 22 h17 |
| Infiltration of macrophages/microglia in the infarct core | day 7 | day 6- day 814 | 6 h17 |
| Spatial patterns of macrophages/microglia accumulation | "wall-like" accumulation in the outer infarct, sparing the infarct core | "wall-like" accumulation in the outer infarct, sparing the infarct core14 | heterogeneous, extending in distinct patterns on a subcortical to cortical axis17 |
| Accumulation of phagozytes | day 7 | day 5-84 | day 317 |
Time-points of various signs of inflammation after focal cerebral ischemia in macrosphere model, human stroke and tMCAO