Table 1. Summary of TB association genetic studies of NRAMP1/SLC11A1, including TB diagnostic criteria, characterization of controls, and whether there was an association with any SNP in the gene.

Population (Reference)	TB Diagnostic Criteria	Characterization of Controls	Association?
Gambia [80]	Smear +	Healthy blood donors	Yes
Gambia [81]	Smear +	Healthy blood donors
Malawi [82]	Smear + OR culture + OR histology	Unrelated with no history of infectious disease	Yes
Morocco [37]	Culture +	Healthy family members
Tanzania [83]	Culture +	Blood donors	Yes
Guinea [36]	Microscopy (smear +? Culture +?)	Unaffected relatives
South Africa [32]	Smear + OR culture +	Unrelated healthy	Yes
Caucasian and African American [26]	Culture + OR past diagnosis	Household members in close contact	Yes
Caucasian [84]	Culture + OR response to TB treatment	Clinic patients without infectious disease	Yes
Caucasian, African American, and Asian [27]	Culture +	Tuberculin skin test positive
Cambodia [85]	Smear +	Hospital/clinic patients	Yes
China [86]	Smear + OR culture + OR symptoms and radiological evidence; males only	Unrelated healthy males	Yes
Japan [87]	Smear + OR culture +	No history of TB disease	Yes
Japan [88]	Smear +	Random clinic patients	Yes
Taiwanese [89]	Culture +	Clinic patients without pulmonary disease
Japan [90]	Smear +	Healthy blood donors without history of pulmonary or inflammatory disease
Thai [91]	Culture +	Healthy blood bank donors
China [92]	Culture +	Hospital patients and healthy blood donors	Yes
Korea [93]	Culture + (unclear)	No history of TB disease	Yes
Japan [94]	Smear + OR culture +	Unrelated healthy
Poland [38]	Culture +	TST negative

Smear + refers to AFB smear positive. “Culture +” could include more stringent definitions such as culture positive, smear positive, and radiological evidence consistent with TB.

This table is limited to studies published in English so that case and control definitions could be determined. It is also limited to studies of pulmonary TB in all age groups.