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. 2011 Jan 5;8:2. doi: 10.1186/1743-422X-8-2

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Copyright ©2011 Li et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<url>http://creativecommons.org/licenses/by/2.0</url>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Immunosuppressive effects of bac-GX0101 with X0101ΔMeq viruses on immune responses against NDV and AIV inactivated vaccines. A: AIV-H5; B: AIV-H9; C: NDV. One-day-old chickens inoculated intra-abdominally with 1000 PFU of bac-GX0101, GX0101ΔMeq viruses or uninfected CEF cultures from each treatment were vaccinated with 0.3 ml inactive NDV (10⁸EID₅₀/0.1 ml), AIV-H5(10^7.5EID₅₀/0.1 ml) and AIV-H9 (10^7.5EID₅₀/0.1 ml), at days 7 p.i., respectively. On days 28 and 35 post-vaccination, serum was collected to measure the HI antibody titers to NDV, AIV-H5 and AIV-H9. The means ± SD (n = 12) at each time point are shown. The bac-GX0101-infected chickens exhibited weaker humoral immune responses against the inactivated NDV and AIV vaccines compared to the control group on days 28 and 35 after immunization (P < 0.05). The GX0101ΔMeq-infected chickens showed similar antibody lever with the control group (P > 0.05).