Table 4.

Survey, Examination Schedule and Clinical Parameters

Procedure	Initial Screening	Baseline Testing	Procedure Day	Post-Procedure Days 1-2	Month 1 ± 7 days	Month 3 ± 14 days	Month 6 ± 14 days	Month 12 ± 14 days	Years 2-5 ± 60 days (treated subjects)
Health Inventory		X		X	X	X	X	X	X
HRCT Scan performed in certified scanner	X1			X5			X	X7
Chest X-Ray	X2		X5
Pulmonary Rehabilitation - Supervised	16-20 sessions over 6-10 weeks			After discharge for 8-9 weeks
Cotinine, carboxyhemoglobin, or carbon monoxide	X2	X3				X
Photograph	X2			X			X
Blinding assessment questionnaire				X	X	X	X	X
St. George's Respiratory Questionnaire		X3			X	X	X	X	X
Quality of Well-being scale		X3			X	X	X	X	X
Medical History (or interval history)	X2				X	X	X	X	X
ASAPSC (Anesthesia score)		X
Dyspnea Index (modified mMRC)	X2	X3		X	X	X	X	X	X
Physical Exam, to include RR, HR, SpO2		X3			X	X	X	X	X
Electrocardiogram		X3
Spirometry	X2	X3		X	X	X	X	X	X
Body Plethysmography	X2	X3		X	X	X	X	X	X
DLco	X2	X3			X	X	X	X
Echocardiography to rule out pulmonary hypertension and congestive heart failure	X2
Pregnancy test (women of child-bearing age)		X4
CBC, Blood Chemistry Panel		X3			X	X	X	X
PTT/INR/PT (only if on acticoagulation therapy)		X3
Serum Creatinine		X3
Arterial Blood Gases	X2	X3					X
6-Minute Walk (with BORG scores)		X3			X	X	X	X
Cycle Ergometry (work output)		X3					X
Intraveneous antibiotic			X
Begin aspirin			X (post op)
Begin oral antibiotic and give subject pocket ID card				X
1 Within 6 months prior to randomization				5 As soon as possible following treatment, and interpreted by the Bronchoscopy investigator (not the Assessment investigator)
2 Within 4 months prior to randomization
3 Within 4 weeks prior to randomization and following at least 6 weeks of supervised pulmonary rehabilitation				6 Required pre- and post-op.
4 Within 24-hours prior to intervention day				7 CT scan at 12 months for Airway Bypass subjects only