Figure 1.

Myocellular fATPase (A and C) and insulin sensitivity (B and D) as assessed from the OGTT (OGIS) in pGDM compared with CON (A and B) and in IR and IS subgroups of the total cohort according to their insulin sensitivity (OGIS) (C and D). Data are presented as box-and-whisker plots. Boxes delineate lower and upper quartile, whiskers represent minima and maxima, medians are indicated by solid line within boxes, and small circles/asterisks represent experimental outliers. fATPase: pGDM vs. CON (10.6 ± 3.8 µmol ⋅ mL muscle⁻¹ ⋅ min⁻¹ vs. 12.1 ± 1.4 µmol ⋅ mL muscle⁻¹ ⋅ min⁻¹; P < 0.12, **after log transformation: P < 0.03), OGIS (glucose clearance): pGDM vs. CON (447 ± 67 mL ⋅ min⁻¹ ⋅ m⁻² vs. 508 ± 87 mL ⋅ min⁻¹ ⋅ m⁻²; P < 0.05), fATPase: IR vs. IS (10.7 ± 3.7 µmol ⋅ mL muscle⁻¹ ⋅ min⁻¹ vs. 11.4 ± 3.0 µmol ⋅ mL muscle⁻¹ ⋅ min⁻¹; P = 0.6 NS), OGIS (glucose clearance): IR vs. IS (402 ± 38 mL ⋅ min⁻¹ ⋅ m⁻² vs. 528 ± 46 mL ⋅ min⁻¹ ⋅ m⁻²; P < 0.0001).