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. 2011 Jan 20;6(1):e16062. doi: 10.1371/journal.pone.0016062

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Yuan et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Angiogenesis phenotypes of microvessels evaluated by immunohistochemical staining of tumor xenografts overexpressing different VEGF isoforms. (A) Immunohistochemical staining of tumor microvessels (brown color, ×100 in main panel, ×400 in the inset) in tumor xenografts. (B) The microvessel density was highest in the VEGF189-overexpressing tumors, intermediate in the VEGF165-overexpressing tumors, and lowest in the VEGF121-overexpressing tumors. (C) The number of vessels with a diameter larger than 15 µm per tumor section in the tumor xenograft was highest in the VEGF121-overexpressing tumors, intermediate in the VEGF165-overexpressing tumors, and lowest in the VEGF189-overexpressing tumors. Differences between VEGF-overexpressing and mock tumors were significant at the *p<0.05, **p<0.01, ***p<0.001, and ****p<0.0001 levels.