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. 2011 Jan 20;6(1):e16397. doi: 10.1371/journal.pone.0016397

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Tsagaratou et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A) Ten control (4 Cyld ^flx9/+ and 6 Cyld ^flx9/+ LysMcre) and eight M-Cyld^Δ9 mice were subjected to LPS induced endotoxic shock (32 mg LPS/kg) and survival was monitored for the next 5 days. M-Cyld^Δ9 mice exhibited increased resistance to endotoxemia in comparison to control mice. Data are depicted as mean absolute numbers (±SEM) from n = 10 control and 8 M-Cyld^Δ9 mice at 8 weeks of age. (p value = 0,02 as assessed by Student's unpaired t test). B) Concentrations of TNFα were measured by enzyme-linked immunosorbent assay in supernatants from control and M-Cyld^Δ9 BMDMs before and 24 h after treatment with 100 ng/mL LPS. The results shown are the means (±S.D.) of triplicate measurements. Control BMDMs were isolated from 3 wild type and 4 Cyld^flx9/+LysMCre mice and M-Cyld^Δ9 BMDMs were isolated from 4 mice.