Table 1. Age-related changes in ECM components and potential effects on tumor progression.

	Promoting	Inhibiting
Collagen I	Increased stiffness	Decreased synthesis/density Increased fragmentation
Laminin	Cleavage and/or loss of LM332 (α3β3γ2) Increased expression of LM α4 and β1 chains	LM332 (α3β3γ2) expression with polarization of epithelial cells Increased expression of LM α4 and β2 chains
TSP1	Long term interactions with VEGF	Increased expression– inhibition of angiogenesis via multiple mechanisms
SPARC	Interactions with Collagen I synthesis and processing Cleavage into pro-angiogenic forms	Increased expression– inhibition of GF effects on endothelial cells
Hyaluronan	Increases in total Hyaluronan	Decrease in HA turnover/generation of LMW-HA forms