Table 3.
Maturational Changes (Birth to 12 Weeks) Amongst Exposed Uninfected and HIV-1 Infected Infants whose Mothers were Given NVP
| Infant Group | Birth NVP | 6 Weeks NVP | 12 Weeks NVP | |||
|---|---|---|---|---|---|---|
| Haematologic Parameter Median (IQR) (min; max) |
EU | HIV-1 Infected | EU | HIV-1 Infected | EU | HIV-1 Infected |
| No. of infants | 113 | 15 | 258 | 24 | 171 | 20 |
| Haemoglobin(g/dL) | 17.6 (15.9-19.5) (10.9;23) |
17.6 (15.8-19.1) (9.6;21.3) |
11.2 (10.5-12) (2;16.3) |
11 (9.7-12.3) (5;18) |
11.6 (10.9-12) (6;14.8) |
11 (10.6-11.4) (8.9;12.1) |
| MCV(fL) | 108 (102-111) (82;118) |
106 (103-108) (93;112) |
92 (88-95) (70;190) |
88 (85-93.8) (79;101) |
83 (80-86) (69;92) |
84 (81-85.8) (75;89) |
| Absolute Counts (/µL) | ||||||
| Platelets(x103) | 237 (178.5-280.5) (13;413) |
204 (173-261) (41;283) |
420 (334-529) (3.1;805) |
362.5 (304-451.3) (97;676) |
442 (363-532) (35;819) |
260 (190.8-383.3) (35;544) |
| RBC(x106) | 4.9 (4.4 -5.3) (3;6.8) |
5 (4.3-5.2) (2.9;5.7) |
3.5 (3.2-3.9) (0.7;306) |
3.6 (3.2-3.9) (1.5;4.9) |
4.1 (3.8-4.3) (2;5.2) |
3.8 (3.7-3.9) (3.1;4.2) |
| WBC(x103) | 15.6 (12.9-19.3) (6.6;33) |
16.3 (12.4-21.8) (9.1;31) |
9.1 (7.3-11.1) (0.1;36.3) |
12.4 (8.5-16) (2.8;25) |
8.6 (7.1-10.7) (0.7;24) |
9.3 (6.7-12.9) (0.1;16.3) |
| Neutrophils(x103) | 9.1 (7-11.1 ) (2.8;20.9) |
9.4 (8.3-12.5) (4.5;15.5) |
1.8 (1.4-2.7) (0.03;11.5) |
2.3 (1.5-3) (0.2;4.8) |
1.8 (1.2-2.5) (0.14;7.7) |
1.7 (1.4-2.2) (0.54;4.9) |
| Lymphocytes(x103) | 3.6 (2.9-4.4) (1.5;7.3) |
3.5 (3.1-4.8) (1.9;9.7) |
5.4 (4.5-7) (0.05;24.5) |
7 (5.3-9.9) (1.8;13.3) |
5.5 (4.3-7.1) (0.5:14.5) |
5.5 (3.5-7.1) (0.1;12.1) |
| Monocytes(x103) | 1.6 (1.2-2.1) (0.06;4.1) |
1.6 (1.1-2.1) (0.56;2.5) |
1 (0.7-1.3) (0.01;6.4) |
1.4 (1.1-2.1) (0.2;6) |
0.79 (0.57-1.1) (0.04;3) |
1.3 (0.56-1.5) (0.02;3.4) |
| Eosinophils(x103) | 0.27 (0.2-0.39) (0.04;0.6) |
0.28 (0.17-0.33) (0.05;0.5) |
0.24 (0.16-0.36) (0;2.3) |
0.35 (0.13-0.49) (0.06;4.7) |
0.24 (0.13-0.35) (0.01;1.2) |
0.3 (0.1-0.6) (0.02;2.3) |
| Basophils(x103) | 0.5 (0.23-1.3) (0.04;4.1) |
0.47 (0.15-1.38) (0.08;3.9) |
0.1 (0.07-0.16) (0.02;2.26) |
0.28 (0.13-0.33) (0.04;1.22) |
0.1 (0.06-0.14) (0;0.48) |
0.16 (0.09-0.26) (0.01;0.57) |
| Blood Differential (%) | ||||||
| Neutrophils | 59.3 (52.6-65) (37.3;73.9) |
60 (51.4-66.1) (39.4;76.4) |
21.4 (17.3-27.5) (3.6;52.7) |
18.8 (15.1-25.2) (6.3;41.1) |
20.3 ( 14.9-27.6) (4.1;65.1) |
20 (12.2-25.1) (8.5;40) |
| Lymphocytes | 23.1 (18.2-28.4) (10.7;49.7) |
21.5 (18.5-31.8) (13.1;44.2) |
62.6 (56.3-68) (32.8;86.8) |
57.7 (51.6-65.9) (44.6;79.7) |
65.8 (57.6-72.1) (23.7;86.9) |
60 (50.4-69.9) (44.8;78.9) |
| Monocytes | 10.3 (9.1-12.2) (0.9;22) |
10.2 (9-11.1) (4.5;14.1) |
10.6 (8.8-12.9) (0.7;31.7) |
12.4 (10.3-14.5) (4.1;31.5) |
8.6 (6.6-11.3) (0.8;22.9) |
11.5 (9.4-15.7) (7;23.6) |
| Eosinophils | 1.7 (1.3-2.3) (0.5;4.9) |
1.6 (1.2-1.9) (0.5;2.3) |
2.7 (1.7-3.8) (0.1;25.5) |
2.5 (1.4-5.2) (0.3;28.2) |
2.5 (1.6-4.2) (0.2;15.4) |
3 (1.7-6.9) (0.2;17.4) |
| Basophils | 3.2 (1.6-8.8) (0.5;21.4) |
2.9 (1.4-8.6) (0.6;12.6) |
1.1 (0.9-1.4) (0.3;38.3) |
2 (1.5-2.5) (0.6;5.1) |
1 (0.9-1.3) (0.4;3.3) |
1.7 (1.3-2.3) (0.7;9.7) |
IQR: interquartile range (25th and 75th percentiles).
Min: lowest value for the haematologic parameter; max: highest value for the haematologic parameter.