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. Author manuscript; available in PMC: 2011 Dec 1.
Published in final edited form as: Cell Metab. 2010 Dec 1;12(6):606–618. doi: 10.1016/j.cmet.2010.11.009

Figure 2. Hepatic glucose production is impaired in SRC-1 KO mice.

Figure 2

A) In vivo glucose production is decreased in SRC-1 KO mice. Glucose production was performed on SRC-1 null and WT mice after an overnight fast (16h) in order to assess basal hepatic glucose production (n = 5 mice per group).

B-C) SRC-1 affects glucose production in primary hepatocytes. B: Measurement of glucose production in primary hepatocytes from WT or SRC-1 null animals after induction of gluconeogenesis with dexametasone and forskolin. C: Measurement of basal glucose production 48 h after overexpression of SRC-1, or as a control, GFP.

Data are represented as mean ± SEM. Unpaired student's t-test was used for evaluation of statistical significance. One asterisk indicates p < 0.05, two asterisks indicate p < 0.01 and three asterisks indicate p < 0.005.