FIGURE 7.

A model showing relative roles played by replication fork associated proteins TOF1, CSM3, RRM3, and DIA2 in the maintenance of genome stability. The model, based on epistasis analysis and biochemical assays described in the text, suggest that TOF1 and RRM3 on the one hand and TOF1 and DIA2 on the other, act in parallel pathways to contribute to genome stability. The model has taken into consideration the fact that dia2Δrrm3Δ is synthetically lethal and therefore RRM3 and DIA2 are likely to function in parallel pathways.