FIGURE 6.
p27RF-Rho is required for murine melanoma lung colonization in vivo. Localization of tumor cells to the lung 1 or 24 h following injection into the tail vein of mice is shown. a, localization of a mixture of B16F0 (labeled with CellTracker Green) and B16F10 cells (labeled with CellTracker Orange). c, localization of a mixture of control B16F10 cells (expressing sh-LacZ, labeled with CellTracker Green) and B16F10 cells depleted for p27RF-Rho (expressing sh-p27RF1, labeled with CellTracker Orange). b and d, the numbers of cells in a and c are presented in b and d, respectively.